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Archive for September 14th, 2007

STOCKHOLM (AFP) — European nations could face further outbreaks of the mosquito-borne chikungunya virus following recent cases detected in Italy, health experts gathered here said Friday.

“Similar conditions that resulted in the establishment of local transmission in Ravenna (northern Italy) apply as well in other areas of Europe where the mosquito is present, for example the southern parts of France, the coastal areas of Spain,” said Denis Coulombier, head of the preparedness and response unit for the European Centre for Disease Prevention and Control (ECDC).

One expert has said that the Italian cases could be the first outbreak outside the tropics. It was apparently caused by a foreigner arriving in Italy from India.

A total of 78 cases have been confirmed in Italy, while 254 others are suspected, said Stefania Salmaso, director of the National Centre for Disease Surveillance and Health Promotion at the Italian Public Health Institute, who …


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This report summarizes 2007 West Nile virus (WNV) surveillance data reported to CDC through ArboNET as of 3 a.m. Mountain Daylight Time, September 11, 2007. A total of 38 states have reported 1,395 cases of human WNV illness to CDC (Figure, Table). A total of 770 (56%) cases for which such data were available occurred in males; median age of patients was 49 years (range: 15 months-96 years). Dates of illness onset ranged from January 8 to September 7; a total of 38 cases were fatal.

[ILLUSTRATION OMITTED]

A total of 136 presumptive West Nile viremic blood donors (PVDs) have been reported to ArboNET during 2007. Of these, 33 were reported from California; 20 from Texas; 13 from Oklahoma; 11 from South Dakota; nine from Minnesota; seven each from Missouri and North Dakota; five from Colorado; four from Kentucky and Mississippi; three each from Iowa, Nebraska, New Mexico, Puerto Rico, and Utah; and one each from Arizona, Louisiana, Montana, North Carolina, Pennsylvania, South Carolina, Virginia, and Wyoming. Of the 136 PVDs, two persons (median age: 66 years; range: 60-71 years) subsequently had neuroinvasive illness, and 31 persons (median age: 49 years; range: 18-79 years) subsequently had West Nile fever.

In addition, 951 dead corvids and 292 other dead birds with WNV infection have been reported in 29 states and New York City during 2007. WNV infections have been reported in horses in 26 states, one canine in Oregon, 11 squirrels in California, and three unidentified animal species in Idaho and Montana. WNV seroconversions have been reported in 316 sentinel chicken flocks in nine states (Arizona, Arkansas, California, Delaware, Florida, Iowa, North Dakota, Oregon, and Utah) and Puerto Rico. A total of 5,172 WNV-positive mosquito pools have been reported from 35 states and New York City.

Additional information about national WNV activity is available from CDC at http://www.cdc.gov/ncidod/dvbid/ westnile/index.htm and at http://westnilemaps.usgs.gov.

TABLE. Number of human cases of West Nile virus (WNV) illness, by
state--United States, 2007 *

                                       West            Other
                  Neuroinvasive        Nile          clinical/
                     disease           fever        unspecified
State               ([dagger])      ([section])    ([paragraph])

Alabama                 12               1               0
Arizona                 10               4               2
Arkansas                 5               1               0
California              73             113              12
Colorado                10              62               0
Connecticut              3               1               0
Florida                  3               0               0
Georgia                  8               6               2
Idaho                    1              69               0
Illinois                14               4               1
Iowa                     5               7               0
Kansas                   9              12               0
Kentucky                 1               0               0
Louisiana                1               1               0
Maryland                 0               0               1
Massachusetts            0               1               0
Michigan                 1               0               0
Minnesota               29              41               0
Mississippi             17              27               0
Missouri                14               4               0
Montana                 28              72               0
Nebraska                 8              62               0
Nevada                   1               2               0
New Mexico              17               8               0
New York                 1               0               0
North Dakota            23             161               0
Ohio                     1               2               0
Oklahoma                24              15               1
Oregon                   3               8               0
Pennsylvania             1               0               0
South Carolina           0               2               0
South Dakota            37             123               0
Tennessee                2               1               0
Texas                   34               9               0
Utah                     6               6               0
Virginia                 2               0               0
Wisconsin                2               2               0
Wyoming                 10             123              10

Total                  416             950              29

                      Total
                     reported
State               to CDC **      Deaths

Alabama                 13            3
Arizona                 16            0
Arkansas                 6            1
California             198           10
Colorado                72            1
Connecticut              4            0
Florida                  3            1
Georgia                 16            0
Idaho                   70            0
Illinois                19            1
Iowa                    12            0
Kansas                  21            0
Kentucky                 1            0
Louisiana                2            0
Maryland                 1            0
Massachusetts            1            0
Michigan                 1            0
Minnesota               70            0
Mississippi             44            1
Missouri                18            0
Montana                100            3
Nebraska                70            3
Nevada                   3            0
New Mexico              25            1
New York                 1            0
North Dakota           184            2
Ohio                     3            0
Oklahoma                40            4
Oregon                  11            0
Pennsylvania             1            0
South Carolina           2            0
South Dakota           160            4
Tennessee                3            0
Texas                   43            2
Utah                    12            0
Virginia                 2            0
Wisconsin                4            0
Wyoming                143            1

Total                1,395           38

* As of September 11, 2007.

([dagger]) Cases with neurologic manifestations (i.e., West Nile
meningitis, West Nile encephalitis, and West Nile myelitis).

([section]) Cases with no evidence of neuroinvasion.

([paragraph]) Illnesses for which sufficient clinical information was
not provided.

** Total number of human cases of WNV illness reported to ArboNET by
state and local health departments.

COPYRIGHT 2007 U.S. Government Printing Office
COPYRIGHT 2008 Gale, Cengage Learning

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Leiden, The Netherlands, September 14, 2007 - Dutch biotechnology
company Crucell N.V. (Euronext, NASDAQ: CRXL, Swiss Exchange: CRX)
today announced that its researchers have discovered a monoclonal
antibody that is active against H5N1 avian influenza. The studies
will be presented at the 5th International Bird Flu Summit scheduled
for September 27 and 28 in Las Vegas, Nevada.

Crucell researchers produced antibodies in PERC6® cells and tested
their biophysical and immunological properties.

“Using phage display technology a set of human monoclonal antibodies
active against a broad range of distinct H5N1 strains was developed,”
said Crucell Chief Scientific Officer Dr. Jaap Goudsmit. “We will
show the ability of these antibodies to prevent infection as well as
to prevent and cure disease caused by H5N1 virus in mice.”

Crucell will provide more information about the research findings
during the two-day conference in Las Vegas.

About Crucell

Crucell N.V. (Euronext, NASDAQ: CRXL; Swiss Exchange: CRX) is a
biotechnology company focused on research, development and worldwide
marketing of vaccines and antibodies that prevent and treat
infectious diseases. Its vaccines are sold in public and private
markets worldwide. Crucell’s core portfolio includes a vaccine
against hepatitis B, a fully-liquid vaccine against five important
childhood diseases, and a virosome-adjuvanted vaccine against
influenza. Crucell also markets travel vaccines, such as the only
oral anti-typhoid vaccine, an oral cholera vaccine and the only
aluminium-free hepatitis A vaccine on the market. The Company has a
broad development pipeline, with several Crucell products based on
its unique PER.C6® production technology. The Company licenses this
and other technologies to the biopharmaceutical industry. Important
partners and licensees include DSM Biologics, sanofi aventis, GSK and
Merck & Co. Crucell is headquartered in Leiden (the Netherlands),
with subsidiaries in Switzerland, Spain, Italy, Sweden, Korea and the
US. The Company employs over a 1000 people. For more information,
please visit www.crucell.com .

Forward-looking statements

This press release contains forward-looking statements that involve
inherent risks and uncertainties. We have identified certain
important factors that may cause actual results to differ materially
from those contained in such forward-looking statements. For
information relating to these factors please refer to our Form 20-F,
as filed with the U.S. Securities and Exchange Commission on June 13,
2007, and the section entitled “Risk Factors”. The Company prepares
its financial statements under generally accepted accounting
principles in the United States (US GAAP) and Europe (IFRS).

For further information please contact:

Media:                            Investors/Analysts:

Barbara Mulder                    Oya Yavuz
Director Corporate Communications Director Investor Relations
Tel: 31-(0) 71 519 7346           Tel. +31-(0) 71-519 7064
 press@crucell.com                   ir@crucell.com
 www.crucell.com                     www.crucell.com

Copyright © Hugin ASA 2007. All rights reserved.

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